Prescribing Trends: The Harsh Reality
A must-read paper for all clinicians and their patients.
By Editorial Staff
From the Annals of Family Medicine1 comes one of the most important studiesto date in the effort to define and understand how drug companies are influencing both the practice of medicine and the health of patients who seek care from medical providers. Conducted by a pair of anthropologists from Michigan State University, the study examines the impact of lower diagnostic thresholds, clinician rewards systems and the prescribing cascade on the health of patients diagnosed with diabetes and hypertension.
The authors lay the foundation for their study by noting, "Spending on prescription drugs in the Unites States has risen nearly 6-fold since 1990, reflecting substantial increases in treatment of chronic conditions and subsequent polypharmacy. As many as 45% of Americans have at least 1 diagnosed chronic condition, and 60% of the most prescribed medications were for hypertension, high cholesterol levels and diabetes. The Centers for Disease Control and Prevention estimates that 11% of the US population and 40% of people older than age 60 take 5 medications or more."
In conducting the study, the authors focused "on the sociocultural aspects of clinical interactions and communication, and were less concerned with the specific content of treatment approaches." They studied primary care clinicians and their patients over a two-year period (2009-2010), with specific emphasis on management of type 2 diabetes and hypertension, two of the most common chronic health conditions. As the study progressed, the authors realized the overwhelming prevalence of prescription drug use in managing these two conditions and thus focused on their influence more closely.
Lower Diagnostic Thresholds
Lower diagnostic thresholds mean that more people are diagnosed with a disease they didn't previously have. The authors point to changes in the diagnosis of diabetes, hypertension and their "pre-" conditions as increasing the number of people subjected to intense prescription management, suggesting that an estimated 10 million additional people are being treated for diabetes, and an additional 22 million for hypertension, due to these lower thresholds.
In 1998, the fasting plasma glucose level that defined a person as diabetic was lowered from 140 to 126. This resulted in an additional 10.3 million people being medically defined as diabetics. The prediabetes fasting glucose level was established at 110 in 1998 and changed to 100 in 2003, resulting in many more pre-diabetics.
In 1993, the blood pressure definition for hypertension was lowered from 160/95 to 140/90 in non-diabetic patients. In 1998, the hypertension blood pressure definition for diabetics was established at 130/80, lower than that of non-diabetics. These changes resulted in an estimated 22 million additional hypertension diagnoses. The prehypertension definition was also established in 1998 at 120/80.
Medical doctors are monitored and rewarded for keeping their patients below certain standards that stem from established guidelines. But "the committees and organizations setting the standards often have substantial pharmaceutical industry support and include many individuals with industry ties." According to the authors, "many insurance companies assess individual clinicians on the basis of whether their patients meet these standards, often paying substantial bonuses that encourage clinicians to respond to marginal test results with aggressive use of pharmaceuticals."
The Prescribing Cascade
Prescription drugs can have adverse impacts on patients, producing symptoms that prompt the prescribing of additional drugs. This is particularly true for patients of clinicians who fail to recognize these adverse reactions. Two-thirds of patients "reported experiencing symptoms they attributed to their diabetes medications, hypertension medications, or both," with several patients hospitalized because of symptoms, prompting a medication change.
In this study, 89% of the patients "reported taking multiple medications, averaging 4.8 prescriptions with more than half (51%) taking 5 or more." In many cases, the patients were expected to continue taking these medications "permanently."
Real People, Real Problems
One of the things that makes this paper so interesting is the approach taken by the authors. They interviewed 58 clinicians and 74 patients for about an hour each, providing insightful clinician comments and patient vignettes that are included in the study:
A Chance to Change
In their concluding remarks, the authors call for a reform on how much influence the pharmaceutical industry has on the practice of medicine: "At a minimum, we urge policies excluding individuals or organizations with financial conflicts of interest from involvement with guideline-writing panels. The presumption that mere disclosure resolves such conflicts must be rejected." They also suggest that physicians "be discouraged from seeing drug representatives."
Editor's Note: This paper is a must read for every doctor of chiropractic and their patients. It is written in an informative style that almost anyone can understand. Please print out a copy for your reception area. Click here.
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